Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.
Interventions for Patients With Alzheimer's Disease and Dysphagia
The overall purpose of this project is to develop effective dysphagia rehabilitative
interventions for patients with Alzheimer's Disease and related dementias at risk for
pneumonia development.
Nicole Rogus-Pulia, PhD
All
50 Years to 99 Years old
N/A
This study is NOT accepting healthy volunteers
NCT03682081
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Inclusion criteria (patients):
• Age 50-99
• English speaking
• Diagnosis of dementia or cognitive impairment or memory loss
• Clinical Dementia Rating (CDR) scale score between 0.5 and 2.0
• Actively involved caregiver
• Resides at home, assisted living facility, or long-term care facility
Inclusion criteria (caregivers)
• English speaking
• Age 18 and older
• Contact with patient at least 1 time a week
• Has access to a working telephone
Exclusion criteria (patients):
• Dementia due to cerebrovascular disease as primary cause
• History of head and neck cancer or other structural deformity that can affect
swallowing
• Allergy to barium
• Currently breastfeed or pregnant or planning to become pregnant
Exclusion criteria (caregivers):
• Lacks ability to give consent
Dementia, Dysphagia, Alzheimer Disease, Alzheimer's disease, Aphagia and dysphagia, Dementia in other diseases classified elsewhere, Mild Cognitive Impairment, Unspecified dementia, Other, Aging & Geriatrics, Food & Nutrition
Immunonutrition Supplementation for Improved Burn Wound Healing in Older Adults
This pilot study aims to assess the feasibility of providing immunonutrition supplementation
to older burn patients (age 55 and older) and its impact on burn wound healing. Supplements
containing arginine and omega 3 fatty acids have been shown to have beneficial effects on
healing in other types of wounds but data within the burn population remains limited. 20
participants will be randomized into two arms, immunonutrition or conventional supplement and
can expect to be on study for 3 months.
Rebecca Busch
All
55 Years and over
N/A
This study is NOT accepting healthy volunteers
NCT04725071
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Inclusion Criteria:
• Subject has partial of full thickness thermal injury of 1-15% of total body surface
area (TBSA)
• Subject has an inpatient admission for their burn
• Subject or authorized decision maker understands the study procedures and can provide
informed consent to participate in the study and authorization for release of relevant
protected health information to the study investigator
Exclusion Criteria:
• Subject with inhalation injury and/or intubation
• Subject receiving immunosuppressive medications including chronic steroids, immune
modulating medications, and chemotherapy prior to admission
• Subject with pre-existing severe chronic liver disease or end stage renal disease
Burn Wound, Burn of unspecified body region, unspecified degree, Burns and corrosions of external body surface, Burns involving 10-19% of body surface area, Burns involving less than 10% of body surface, Other, Injury, Trauma & Emergency Medicine, Food & Nutrition, Skin & Dermatology
The goal of this study is to establish a birth cohort that collects prenatal and early life
biosamples and environmental samples and rigorously phenotypes young children for food
allergy and Atopic Dermatitis (AD) to identify prenatal and early life markers of high risk
for food allergy and AD, as well as biological pathways (endotypes) that result in these
conditions.
Primary Objectives:
- To study the role and interrelationships of established and novel clinical,
environmental, biological, and genetic prenatal and early-life factors in the
development of allergic diseases through age 3 years, with an emphasis on atopic
dermatitis and food allergy
- To apply systems biology to identify mechanisms and biomarkers underlying the
development of food allergy, atopic dermatitis, and their endotypes
- To collect, process, and assay or store environmental and biological samples for current
and future use in the study of allergic disease development
James Gern
All
0 Years and over
NA
This study is also accepting healthy volunteers
NCT04798079
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Inclusion Criteria:
Pregnant Women-
Pregnant women who meet all of the following criteria are eligible for enrollment as study
participants:
1. Age 18 years or older
2. Able to understand the oral and written instructions associated with study visits and
procedures and provide informed consent
3. Pregnant at any stage
4. Planning to give birth at a study-site designated center
5. Agrees to enroll offspring into the study at birth
6. In the case of multiple gestation, agrees to enroll only one child who will be
selected by randomized birth order
Biological Fathers-
Biological fathers who meet all of the following criteria are eligible for enrollment as
study participants:
1. Age 18 years or older
2. Able to understand the oral and written instructions associated with study visits and
procedures and provide informed consent
Exclusion Criteria:
Pregnant Women-
Pregnant women who meet any of these criteria are not eligible for enrollment:
1. Inability or unwillingness to comply with study protocol
2. Serious pregnancy complication (in the judgement of the investigator) prior to
enrollment
3. Fetus has a major chromosomal anomaly
4. Plans to move and would not be available for in-person visits at a study site
5. Plans to give up her child for adoption at birth
6. Pregnancy is the result of an egg donation
Infants-
Infants who meet any of these criteria are not eligible for enrollment:
1. Delivered earlier than 34 weeks of gestation
2. Sibling already enrolled
3. Born with a significant birth defect or medical condition, and in the judgment of the
investigators, participation is not in the infant's best interest
Biological Father-
1. Biological fathers who are unable or unwilling to comply with the study protocol as it
pertains to the biological father's participation are not eligible for enrollment
----Note Regarding Legal Guardians who are not the Biological Parents:
1. At screening for enrollment of either the mother or the child, if the biological
mother intends to give the infant up for adoption, neither the mother nor the child
are eligible for enrollment
2. If the biological mother gives up legal guardianship of the child during the child's
follow-up period, the child may remain enrolled as long as the new legal guardian:
• Agrees to meet the child's study requirements, and
• Provides written informed consent for the child's continued participation.
3. Throughout the protocol where it refers to the mother, father, or parent answering
questionnaires about the child or collecting samples from the child and the child's
primary home, the legal guardian who provides consent for the child's participation
may complete those procedures
Vitamin A Status in Patients With Vocal Fold Leukoplakia
This study will determine systemic vitamin A status and lesion histopathology of participants
with vocal fold hyperkeratosis resulting in clinical leukoplakia.
Nathan Welham
All
18 Years and over
N/A
This study is NOT accepting healthy volunteers
NCT05323292
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Inclusion Criteria:
1. Willing to provide informed consent.
2. Willing to comply with all study procedures and be available for the duration of the
study.
3. Ability to take oral medication.
4. At least 18 years of age.
5. Leukoplakia study groups:
1. Leukoplakia due to hyperkeratosis with dysplasia: biopsy-confirmed diagnosis of
hyperkeratosis with dysplasia.
2. Leukoplakia due to hyperkeratosis with no dysplasia: biopsy-confirmed diagnosis
of hyperkeratosis with no dysplasia.
6. Control group: Laryngoscopy showing no evidence of vocal fold mucosal disease.
Exclusion Criteria:
1. History of malignant vocal fold mucosal pathology.
2. History of metabolic or liver disorder.
3. History of anorexia or bulimia.
4. Pregnant, lactating, or planning on becoming pregnant during the study period.
5. History of >4.5 kg weight loss in the past 90 days.
6. Medical or other inability to complete an 8 hour fast.
7. Acute respiratory or gastrointestinal illness.
8. Currently incarcerated.
9. Impaired decision-making capacity.
10. No or limited English speaking ability; illiterate or low-literacy ability.
11. Profound visual or hearing impairment that limits written or verbal communication.
12. Status relationship with a member of the study team.
13. Not suitable for study participation due to other reasons at the discretion of the
investigators.
Diseases of vocal cords and larynx, Other, Vitamin A, Vitamin A Deficiency, Leukoplakia, Vocal Cord Neoplasm, Healthy Volunteers, Food & Nutrition
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