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Suggestions within category "Food & Nutrition"

Obesity Probiotics Vitamin Deficiency Vitamin Supplementation
2 Study Matches

Immunonutrition Supplementation for Improved Burn Wound Healing in Older Adults

This pilot study aims to assess the feasibility of providing immunonutrition supplementation to older burn patients (age 55 and older) and its impact on burn wound healing. Supplements containing arginine and omega 3 fatty acids have been shown to have beneficial effects on healing in other types of wounds but data within the burn population remains limited. 20 participants will be randomized into two arms, immunonutrition or conventional supplement and can expect to be on study for 3 months.
Rebecca Busch
All
55 Years and over
N/A
This study is NOT accepting healthy volunteers
NCT04725071
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Inclusion Criteria:

• Subject has partial of full thickness thermal injury of 1-15% of total body surface area (TBSA)
• Subject has an inpatient admission for their burn
• Subject or authorized decision maker understands the study procedures and can provide informed consent to participate in the study and authorization for release of relevant protected health information to the study investigator
Exclusion Criteria:

• Subject with inhalation injury and/or intubation
• Subject receiving immunosuppressive medications including chronic steroids, immune modulating medications, and chemotherapy prior to admission
• Subject with pre-existing severe chronic liver disease or end stage renal disease
Burn Wound, Burn of unspecified body region, unspecified degree, Burns and corrosions of external body surface, Burns involving 10-19% of body surface area, Burns involving less than 10% of body surface, Other, Injury, Trauma & Emergency Medicine, Food & Nutrition, Skin & Dermatology
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Vitamin A Status in Patients With Vocal Fold Leukoplakia

This study will determine systemic vitamin A status and lesion histopathology of participants with vocal fold hyperkeratosis resulting in clinical leukoplakia.
Nathan Welham
All
18 Years and over
N/A
This study is NOT accepting healthy volunteers
NCT05323292
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Inclusion Criteria:
1. Willing to provide informed consent. 2. Willing to comply with all study procedures and be available for the duration of the study. 3. Ability to take oral medication. 4. At least 18 years of age. 5. Leukoplakia study groups: 1. Leukoplakia due to hyperkeratosis with dysplasia: biopsy-confirmed diagnosis of hyperkeratosis with dysplasia. 2. Leukoplakia due to hyperkeratosis with no dysplasia: biopsy-confirmed diagnosis of hyperkeratosis with no dysplasia. 6. Control group: Laryngoscopy showing no evidence of vocal fold mucosal disease.
Exclusion Criteria:
1. History of malignant vocal fold mucosal pathology. 2. History of metabolic or liver disorder. 3. History of anorexia or bulimia. 4. Pregnant, lactating, or planning on becoming pregnant during the study period. 5. History of >4.5 kg weight loss in the past 90 days. 6. Medical or other inability to complete an 8 hour fast. 7. Acute respiratory or gastrointestinal illness. 8. Currently incarcerated. 9. Impaired decision-making capacity. 10. No or limited English speaking ability; illiterate or low-literacy ability. 11. Profound visual or hearing impairment that limits written or verbal communication. 12. Status relationship with a member of the study team. 13. Not suitable for study participation due to other reasons at the discretion of the investigators.
Diseases of vocal cords and larynx, Other, Vitamin A, Vitamin A Deficiency, Leukoplakia, Vocal Cord Neoplasm, Healthy Volunteers, Food & Nutrition
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